分析静脉滴定治疗13例中重度癌痛患者临床观察

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[摘要] 目的 观察静脉滴定治疗中重度癌痛的疗效及不良反应。 方法 选取13例中重度癌痛住院患者进行静脉滴定,每15分钟通过疼痛数字分级法(NRS)评价患者疼痛变化程度,记录和处理其不良反应,调整静脉用药剂量,24 h后统计静脉累计剂量,通过与控缓释剂阿片类镇痛药物的剂量转换,改用口服剂型或透皮剂维持镇痛。 结果 在所有静脉滴定患者中,在0~3 h内疼痛NRS评分皆下降,3~6 h内NRS评分至少下降3分,24 h镇痛有效率为100%;在毒副作用的观察方面,24 h内发生急性呼吸抑制1例,1~2度急性呕吐5例,3度呕吐1例,头晕8例,经及时治疗后症状好转。 结论 对于中重度癌痛患者,相比于口服速效类阿片类药物或奥施康定等滴定镇痛,静脉滴定具有起效快、镇痛效果肯定等特点,对于住院的中重度癌痛患者,应用静脉滴定安全,毒副作用可控,值得进一步推广应用。
[关键词] 硫酸针;静脉滴定;癌痛
[] B[文章编号] 1673—9701(2012)27—0082—03
Clinical observation of intrenous morphine titration treatment in 13 patients with moderate/severe cancer pain
LIAO Yayong CHEN Yaocheng CHEN Suhong GUAN Jing
Department of Oncology,the Affiliated Jiangmen Hospital ofSouthern Medical University,Jiangmen 529000,China
[Abstract] Objective To observe the effectiveness and adverse reaction of intrenous morphine titration treatment for moderate to severe pain with. Methods In this study,13 hospitalized patients with moderate or severe pain are treated with intrenous morphine titration,evaluating pain patients variations through Numerical Rating Scales(NRS) every 15 minutes,recording and processing the adverse reactions, and adjusting dose,calculating the cumulative dose of morphine Calculate 24 hours later,oral or tranucosal conversion to control pain. Results All patients’NRS scores are reduced in 0—3 hours,NRS score at least reduce three points in 3—6 hours, the pain relief rate was 100% in 24 hours;the commn toxicities were acute respiratory inhibition(1/13),1—2 degrees acute vomiting(5/13),3 degrees vomiting(1/13) and dizzy(8/13). With timely treatment,all these symptoms are under controlled. Conclusion For the patients with moderate to severe pain,compared to the oral opioid to titration analgesia, intrenous morphine titration work faster,has satiied results.For the hospitalized patients with moderate to severe pain,the applic摘自:写毕业论文经典网站www.808so.com
ation of intrenous morphine is safe,and the side effects are under controlled.So it is worth for further promotion and application.
[Key words] Sulfuric acid morphine injection;Intrenous morphine titration;Cancer pain
慢性中重度癌痛常发生于中晚期肿瘤患者,其生活质量受到严重影响。随着WHO癌痛三阶梯止痛治疗方案的制定和实施,许多慢性癌痛患者疼痛得到较好的控制。目前中重度癌痛的滴定镇痛治疗方式主要有口服速效类阿片类以及静脉注射,临床上应用以前者为主,后者应用较少。从2011年4月份开始,笔者所在医院在广东省癌症康复与姑息治疗委员会的指导下成功创建“无痛病房”,遵循《NCCN癌痛治疗指南(2010年)》和卫生部《癌痛治疗规范(2011年)》,使用静脉滴定治疗中重度癌痛患者13例,得到了较好的止痛效果,现报道如下。
1 资料与方法
1.1 一般资料
选择13例在我院止痛门诊治疗疼痛的中重度癌痛患者,其中女3例,男8例,年龄37~79岁,平均(59.5±5.8)岁。原发肿瘤部位:肺癌5例,原发性肝癌3例,乳腺癌3例,结直肠癌2例,全部发生远处转移,其中转移灶有骨、肝、肺、侧胸膜、胸壁、左侧颈部软组织。其中11例重度癌症患者接受过手术、放疗或化疗等治疗,2例患者确诊为晚期癌症后因各种原因未做任何抗肿瘤治疗只行止痛治疗维持生命。所有病例经服用非甾体类镇痛药或其他弱阿片类药物治疗失败,需口服第三阶梯药物治疗。源于:本科论文www.808so.com
摘自:毕业论文 格式www.808so.com

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